A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver’s antidote

wtf genes are prolific dual poison-antidote meiotic drivers

Meiotic drivers are selfish genes that bias their transmission into gametes, defying Mendelian inheritance. Despite the significant impact of these genomic parasites on evolution and infertility, few meiotic drive loci have been identified or mechanistically characterized. Here, we demonstrate a complex landscape of meiotic drive genes on chromosome 3 of the fission yeasts Schizosaccharomyces k...

Arsenic: In Search of an Antidote to a Global Poison

Amir Attaran In 2001, the chief of the United States Agency for International Development (USAID), Andrew Natsios, gave this justifi cation to the US Congress for why the agency opposed giving antiretroviral therapy (ART) to Africans with HIV: “If we had [HIV medicines for Africa] today, we could not distribute them. We could not administer the program because we do not have the doctors, we do ...

Strychnine as an Antidote to Snake-Poison

Experiments on Cobra Poison and on a Reputed Antidote

antidote was repeated several times, ?without any apparent effect, and the rabbit died before the other which had no antidote. The second rabbit, -when oil the point of death, quite unconscious, and with feeble convulsive movements commencing, had its trachea opened and artificial respiration applied. There was no return of consciousness or of voluntury movement ; the tail was observed to move,...

A PoTENtial Antidote

The direct oral anticoagulants (DOACs), which include dabigatran, rivaroxaban, apixaban, and edoxaban, can be given in fixed doses without routine coagulation monitoring. In clinical trials, the DOACs have been shown to be at least as effective as vitamin K antagonists (VKAs), such as warfarin, for stroke prevention in nonvalvular atrial fibrillation and for treatment of venous thromboembolism,...